課程資訊
課程名稱
 生物物理化學導論
INTRODUCTION TO BIOPHYSICAL CHEMISTRY 
開課學期
 96-2 
授課對象
 理學院  化學系  
授課教師
 李弘文 
課號
 Chem3002 
課程識別碼
 203 20220 
班次
  
學分
 2 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期三7,8(14:20~16:20) 
上課地點
 新401 
備註
 外系所生選修需經授課教師同意。本課程中文授課,使用英文教科書。本?
限學士班二年級以上 且 限本系所學生(含輔系、雙修生)
總人數上限：60人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/962biophys 
課程簡介影片
 
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課程概述

(1). Why (and how) bio-macromolecules exist in specific structure?
-- Structure of biomacromolecules and forces stabilizing them
- hydrogen bonding
- electrostatic interaction
- hydrophobic interaction
- protein folding/unfolding

(2). How do protein molecules regulate their activity through binding?
-- Simple chemical equilibrium and kinetics concepts say it all
- ligand binding
- cooperative binding
- enzyme kinetics

(3). How do macromolecules move in the cellular environment?
-- Transport mechanism of biomolecules
- random walk and diffusion
- active transport
- life of E. coli in our body, swimming??

(4). Seeing is believing. How to see biochemical processes at work?
-- Molecular cameras and imaging
- fluorescence imaging
- single-molecule methods
 

課程目標
 (1). 用簡單的化學, 物理概念來解釋生物體系的運作及調控.
(2). 不用背誦, 不用複雜的計算, 也可以認識有趣的生物體系.
 
課程要求
  
預期每週課後學習時數
  
Office Hours
 每週二 14:30~15:30 
指定閱讀
  
參考書目
 No required textbook.

Reference books:
- “Principles of Physical Biochemistry”, by van Holde, Johnson, and Ho
(QP517.P49 V36 2006, 化學系圖書室, 限館內閱覽)
- “Molecular driving forces : statistical thermodynamics in chemistry and
biology”, by Dill (QC311.5 D55 2003, 化學系圖書室, 限館內閱覽)
- “Structure and mechanism in protein science : a guide to enzyme catalysis and
protein folding”, by Alan Fersht (QD431.25.S85 F47 1999, 化學系圖書室, 限館內閱覽)
- “Physical Chemistry: With Applications to the Life Sciences”, by Eisenberg and
Crothers (化學系圖書室訂購中)
- “Random walks in biology”, by Berg (QH323.5 B45 1993, 化學系圖書室訂購中)
- “Molecular and cellular biophysics”, by Jackson (QH505 J33 2006, 化學系圖書室,
限館內閱覽)
- “Biological physics: energy, information, life”, by Nelson (QH505 N37 2004, 化
學系圖書室訂購中)
- “Biological thermodynamics”, by Haynie (QP517.T48 H395 2001, 化學系圖書室訂購中)
- “Protein structure and function”, by Petsko and Ringe (QP551 P3974 2004, 化學
系圖書室訂購中)
 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 期中考 
30% 
  
2. 
 期末考 
40% 
  
3. 
 作業 
30% 
 作業抄襲,該次作業以零分計 
 
課程進度
週次
日期
單元主題
第1週
 2/20  Section 1:
Why (and how) bio-macromolecules exist in specific structure?
-- Structure of biomacromolecules and forces stabilizing them
 
第4週
 3/12  請參閱公告欄有關Assignment 1附加資訊 
第5週
 3/19  Section 2: How do protein molecules regulate their activity through binding? -- Simple chemical equilibrium and kinetics concepts say it all
 
第8週
 4/09  Enzyme Kinetics 
第9週
 4/16  In-class mid-term (Section 1 and 2) 
第10週
 4/23  Section 3: Seeing is believing. How to see biochemical processes at work? -- Molecular cameras and imaging 
第11週
 4/30  停課 
第12週
 5/07  Single-molecule lecture 
第13週
 5/14  Microscope Demonstration in-class 
第14週
 5/21  Section 4: How do macromolecules move in the cellular environment? -- Transport mechanism of biomolecules 
第16週
 6/04  Bacteria Motility